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Biyomalzeme Üretim ve Karakterizasyon Laboratuvarı Direktörü

Duygu Ege şu anda Boğaziçi Üniversitesi'nde profesör olarak görev yapmaktadır. 2022-2023 yılları arasında Erlangen-Nürnberg Üniversitesi Biyomalzemeler Enstitüsü'nde Humboldt bursiyeriydi. Cambridge Üniversitesi'nden Tıbbi Malzemeler alanında doktora derecesine ve Imperial College London'dan Malzeme Bilimi ve Mühendisliği alanında MEng (Lisans + Yüksek Lisans) derecesine (Birinci Sınıf Onur Derecesi) sahiptir. ETH Zürih'te kemik vidalarının üretimi ve karakterizasyonu üzerine yaptığı araştırmalar, ona Londra Imperial College'den Centenary Ödülü'nü kazandırmıştır (2009). Diğer ödülleri arasında, Cambridge Üniversitesi'nde doktora yapmasını sağlayan Dorothy Hodgkin Bursu, Uluslararası Tıp Seramikleri Derneği'nin En İyi Podium Sunumu Ödülü ve ETH Zürih'teki araştırma çalışmaları için IDEA League Hibe'si bulunmaktadır. Şimdiye kadar yaptığı araştırmalar, kemik replasmanı, implant kaplamaları, sinir rejenerasyonu, kas ve kalp doku mühendisliği için biyoaktif ve biyoinert seramikler, karbonlu malzemeler ve doğal polimer kompozitler dahil olmak üzere yeni biyomalzemelerin üretimi ve işlenmesine odaklanmıştır.

Eğitim:

Doktora, Tıbbi Malzemeler, Cambridge Üniversitesi.

Lisans ve Yüksek Lisans, Malzeme Bilimi ve Mühendisliği, Imperial College, Londra.

Deneyim:

ETH Zürih'te kemik vidalarının üretimi ve karakterizasyonu.

Araştırma Alanları:

Laboratuvarımızın odak noktası çok disiplinlidir ve aşağıdaki alanlardaki araştırmaları içermektedir:

• Doku rejenerasyonu

• Enjekte edilebilir iskeletler

• İlaç verme cihazları

• Doku iskeletlerinin 3D baskısı

• Biyomalzeme verilerini analiz etmek için makine öğrenimi modelleri

Ödüller:

• Erlangen-Nürnberg Üniversitesi, Biyomalzeme Enstitüsü Humboldt Bursiyeri (2022-2023)

• Centenary Ödülü, Imperial College, Londra (2009)

• Dorothy Hodgkins Bursu

• En İyi Sözlü Sunum Ödülü, Uluslararası Tıpta Seramik Derneği

• IDEA League Hibe Programı (ETH Zürih’teki araştırma çalışmaları için)

Araştırma Projeleri:

05/2022- 08/2023

Effect of zinc, silver and cerium oxide doped borate bioactive glass- based nanofibers on neural differentiation

Host: Prof. Aldo Boccaccini

Friedrich-Alexander-Universität Erlangen-Nürnberg

Humboldt Fellow as an Experienced Researcher, 3000 EUR per month

Role: Researcher

05/2021-05/2023

The comparison of 3D printed Poly(lactide-co-glycolide) acid (PLGA) and Carboxymethly Cellulose-Gelatin-based Composites

Boğaziçi University Research Project Fund Role: Principle Investigator

03/2020-03/2023

Examination of Osteogenic Gene Expression of Carbon Nanostructure Reinforced Injectable Bone Scaffolds

Boğaziçi University Research Project

Role: Principle Investigator

10/2017-10/2020

Mechanical Properties of Injectable Bone Scaffolds Reinforced with Carbon Nanostructures and Investigation of Its Effect on Osteogenic Differentiation

Scientific Research Council of Turkey (TUBITAK)

12/2017 - 10/2019

Graphene Oxide as a Drug Carrier for Delivery of Zoledronate in Metabolic Bone Disease and Secondary Bone Cancer Treatment,

Boğaziçi University Research Project (Fund: 35.983,34 TL(£7435))

Role: Principle Investigator

11/2016 - 07/2019

Synthesis and Characterization of Bisphosphonate Loaded Injectable Bone Substitutes,

Boğaziçi University Research Project (Fund: 35.998,77 TL)(£8867)

Role: Principle Investigator

03/2016 - 10/2017

Effect of Nano Yttria Containing Zirconium (YSZ) and L-Arginine on Hydroxyapatite (HA) Coatings

Scientific Research Council of Turkey (TUBITAK) Role: Principle Investigator

06/2015- 12/2016

Effect of Graphene Oxide /Biodegradable Nanofiber Composites on Schwann Cell Behavior,

Boğaziçi University Research Project

Role: Principle Investigator

Yayınlar:

1. Arıcı, Ş., Kamali, A. R., & Ege, D. (2024). CMC/Gel/GO 3D-printed cardiac patches: GO and CMC improve flexibility and promote H9C2 cell proliferation, while EDC/NHS enhances stability. Biofabrication, 17(1), 015025.

2. Lu, H. H., Ege, D., Salehi, S., & Boccaccini, A. R. (2024). Ionic medicine: exploiting metallic ions to stimulate skeletal muscle tissue regeneration. Acta Biomaterialia.

3. Apaydın, B. B., Çamoğlu, T., Canbek Özdil, Z. C., Gezen‐Ak, D., Ege, D., & Gülsoy, M. (2024). Chitosan‐enhanced sensitivity of mercaptoundecanoic acid (MUA)‐capped gold nanorod based localized surface plasmon resonance (LSPR) biosensor for detection of alpha‐synuclein oligomer biomarker in parkinson’s disease. Biotechnology and Applied Biochemistry.

4. Wei, S., Liu, Y., Rezaei, A., Ege, D., & Kamali, A. R. (2024). Circular economy approach for thermal regeneration of graphene-encapsulated magnetic nanoparticles as an efficient adsorbent for sustainable wastewater management. Journal of Alloys and Compounds, 1008, 176545.

5. Faramarzi, M., Shabgard, S., Khalili, V., & Ege, D.* (2024). Exploring the effect of chlorhexidine concentration on the biocorrosion behavior of Ti6Al4V for dental implants. Microscopy Research and Technique, 87(7), 1552-1565.

6. Khalili, V., Ghaleh, H., Asl, H. N., Ege, D., Dikici, B., Kaseem, M., ... & Eggeler, G. (2024). Assessing the properties of biodegradable magnesium alloy AZ31 protected by a polymer layer on a plasma electrolytic oxidized (PEO) surface. Surface and Coatings Technology, 131002.

7. Arıcı, Ş., & Ege, D. (2024). Effect of gelatin concentration on the mechanical properties and in vitro degradation behaviour of gelatin/carboxymethyl cellulose-based 3D printed scaffolds. MRS Advances, 1-7.

8. Ege, D.*, & Arıcı, Ş. (2024). Investigation of effect of processing parameters of 3D printed NHS/EDC crosslinked carboxy methyl cellulose/gelatin hydrogels with machine learning techniques. Materials Research Express, 11(4), 045304.

9. Ege, D.*, & Boccaccini, A. R. (2024). Investigating the Effect of Processing and Material Parameters of Alginate Dialdehyde-Gelatin (ADA-GEL)-Based Hydrogels on Stiffness by XGB Machine Learning Model. Bioengineering, 11(5), 415.

10. Liu, Y., Wei, S., Kamali, B. E., Ege, D., & Kamali, A. R. (2024). Ni0. 4Fe2. 6O4/(Fe, Ni)‑carbon core-shell magnetic mesoporous nanostructure for efficient adsorption and photocatalytic degradation of malachite green from wastewater. Journal of Water Process Engineering, 59, 105019.

11. Ege, D.*, Lu, H. H., & Boccaccini, A. R. (2024). Bioactive glass and silica particles for skeletal and cardiac muscle tissue regeneration. Tissue Engineering Part B: Reviews.

12. Kaya, H., Arıcı, Ş., Bulut, O., Bilgili, F., & Ege, D*. (2023). CNT incorporation improves the resolution and stability of porous 3D printed PLGA/HA/CNT scaffolds for bone regeneration. Biomedical Materials, 18(5), 055028.

13. Liu, Y., Sun, T., Ege, D., & Kamali, A. R. (2024). Cobalt Oxide-Decorated on Carbon Derived from Onion Skin Biomass for Li-Ion Storage Application. Metals, 14(2), 191.

14. Ege, D.*, & Kamali, A. R. (2024). XGB Modeling Reveals Improvement of Compressive Strength of Cement-Based Composites with Addition of HPMC and Chitosan. Materials, 17(2), 374.

15. Ege, D., Sertturk, S., Acarkan, B., & Ademoglu, A. (2023). Machine learning models to predict the relationship between printing parameters and tensile strength of 3D Poly (lactic acid) scaffolds for tissue engineering applications. Biomedical Physics & Engineering Express, 9(6), 065014.

16. Kaya, H., Arıcı, Ş., Bulut, O., Bilgili, F., & Ege, D. (2023). CNT incorporation improves the resolution and stability of porous 3D printed PLGA/HA/CNT scaffolds for bone regeneration. Biomedical Materials, 18(5), 055028.

17. Ege, D., Pourshahrestani, S., Iorio, F., Reinfelder, H., de Ligny, D., & Boccaccini, A. R. (2023). Processing and characterization of aligned electrospun gelatin/polycaprolactone nanofiber mats incorporating borate glass (13-93B3) microparticles. Biomedical Materials, 18(5), 055030.

18. Duru, İ., Büyük, N. İ., Torun Köse, G., Marques, D. W., Bruce, K. A., Martin, J. R., & Ege, D. (2023). Incorporating the antioxidant fullerenol into calcium phosphate bone cements increases cellular osteogenesis without compromising physical cement characteristics. Advanced Engineering Materials, 25(17), 2300301.

19. Ege, D.*, Hasırcı V. (2023) “Is 3D printing promising for osteochondral tissue regeneration?” ACS Applied Bio Materials, 6(4), 1431-1444

20. Arıcı, Ş., Kaçmaz, E. G., Kamali, A. R., & Ege, D.* (2023). “Influence of graphene oxide and carbon nanotubes on physicochemical properties of bone cements.” Materials Chemistry and Physics, 293, 126961.

21. Ege, D.*, Nawaz, Q., Beltrán, A. M., & Boccaccini, A. R. (2022). “Effect of Boron-Doped Mesoporous Bioactive Glass Nanoparticles on C2C12 Cell Viability and Differentiation: Potential for Muscle Tissue Application.” ACS Biomaterials Science & Engineering, 8(12), 5273-5283.

22. Ege, D.*, Zheng, K., & Boccaccini, A. R. (2022). “Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions.” ACS Applied Bio Materials, 5(8), 3608-3622.

23. Ege, D*. 2021 "Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted Delivery." Materials, 14: 3332–3353.

24. Oğuz, Ö. D., Ege, D*. 2021 "Effect of Zoledronic Acid and Graphene Oxide on the Physical and In Vitro Properties of Injectable Bone Substitutes." Materials Science and Engineering: C, 120:111758 -111771.

25. Güben E., Arıcı Ş., Bayır D., Bozdağ E., Ege D*. (2020) “Preparation of Calcium Phosphate / Carboxymethyl Cellulose-based Bone Cements” Bioinspired, Biomimetic and Nanobiomaterials 9(3),155-163

26. Boran G., Tavakoli S., Dierking I., Kamali AR., Ege D*. (2020) “Synergistic effect of graphene oxide and zoledronic acid for osteoporosis and cancer treatment” Scientific Reports, 10(1), 1-12

27. Demir Oğuz Ö., Ege D.* (2019). “Preparation of Graphene Oxide-reinforced Calcium Phosphate /Calcium Sulfate/Methylcellulose-based Injectable Bone Substitutes” MRS Communications, 9(4), 1174-1180.

28. Güben E., Ege D.* (2019). “Physico-chemical Effects of Gelatin Addition in Carboxymethylcellulose and Calcium Phosphate Cement-based Nanocomposites” MRS Advances, 1-7.

29. Duru İ., Ege D.* (2018). “Self-Assembly of L-Arginine on Electrophoretically Deposited Hydroxyapatite Coatings” ChemistrySelect, 3(31), 9041-9045.

30. Demir Oğuz Ö., Ege D.* (2018). “Rheological and Mechanical Properties of Thermoresponsive Methylcellulose/Calcium Phosphate-based Injectable Bone Substitutes” Materials, 11(4), 604-621.

31. Kaya H., Bulut O., Kamali AR., Ege D.* (2018). “L-Arginine Modified Multiwalled Carbon Nanotube/Sulfonated Poly(etheretherketone) Nanocomposite Films for Biomedical Applications” Applied Surface Science, 444, 168-176.

32. Tavakoli S.*, Ege D. (2018). “Graphene Oxide as a Drug Carrier for Delivery of Zoledronic Acid in Secondary Bone Cancer Treatment” MRS Advances, 4(21), 1231-1236.

33. Ege D.*, Kamali AR., Boccaccini AR. (2017). “Graphene Oxide/Polymer-based Biomaterials” Advanced Engineering Materials, 19(12), 16-34.

34. Ege D.*, Duru İ., Kamali AR., Boccaccini AR. (2017). “Nitride, Zirconia, Alumina, and Carbide Coatings on Ti6Al4V Femoral Heads: Effect of Deposition Techniques on Mechanical and Tribological Properties” Advanced Engineering Materials, 19(11), 49-54.

35. Duru İ., Ege D.*, Kamali AR. (2016). “Graphene Oxides for Removal of Heavy and Precious Metals from Wastewater” Journal of Materials Science, 51(13), 6097-6116.

36. Öztatli H, Ege D.* (2016). “Physical and Chemical Properties of Poly(l-lactic acid) Graphene Oxide Nanofibers for Nerve Regenerations” MRS Advances, 2(24), 1291-1296.

37. Ege D.*, Best S., Cameron R. (2014). “The Degradation Behaviour of Nanoscale HA/PLGA and TCP/PLGA Composites” Bioinspired, Biomimetic and Nanobiomaterials, 3(2), 85-93.

38. Ege D.,* Lee K., Bismarck A., Serena B., Cameron R. (2011). “Evaluation of the Degradation Properties of Carbonate Substituted Hydroxyapatite Poly(caprolactone) Composites” Key Engineering Materials, 493494, 120-125.

39. Mohn D.*, Ege D.⁺, Feldman K., Schneider Ol., Imfeld T., Boccaccini AR., Stark W. (2010). “Spherical Calcium Phosphate Nanoparticle Fillers Allow Polymer Processing of Bone Fixation Devices with High Bioactivity” Polymer Engineering Science, 50(5), 952-960.

(^+: Bu çalışmaya eşit oranda katkı vermiştir.)

Dersler:

BM 541 Biological Materials

BM 597 Characterisation of Biomedical Samples

BM 682 Phase Transformation and Heat Treatment of Biomaterials