Duygu EGE

Rank & Status: 

Associate Professor

Biography: 

Duygu Ege is currently Associate Prof. at Boğaziçi University, Turkey. She was Humboldt fellow at the University of Erlangen-Nuremberg, Institute of Biomaterials between 2022-2023. She has a PhD in Medical Materials from University of Cambridge and a MEng (Bachelar studies + Master studies) Degree in Materials Science and Engineering (First Class Honours) from Imperial College, London. Her research on production and characterisation of bone screws at ETH Zurich, lead her to receive the Centenary Prize from Imperial College, London (2009). Her other awards include Dorothy Hodgkins Scholarship leading to PhD at University of Cambridge, Best Podium Presentation Award by International Society for Ceramics in Medicine and IDEA League Grant for her research work at ETH Zurich. Our research so far has concentrated on the production and processing of novel biomaterials including bioactive and bioinert ceramics, carbonaceous materials, and natural polymer composites for bone replacement, implant coatings, nerve regeneration, muscle and cardiac tissue engineering.

Education: 

PhD, Medical Materials, University of Cambridge.

BSc and MEng, Materials Science and Engineering, Imperial College, London.

 

Experience: 

Production and characterisation of bone screws at ETH Zurich.

Research Areas: 

The focus of our lab is multidisciplinary including research on

  • tissue regeneration
  • injectable scaffolds
  • drug delivery devices
  • 3D printing of tissue scaffolds
  • Machine learning models for analyzing biomaterials data
Awards: 
  • Humboldt Fellow at the University of Erlangen-Nuremberg, Institute of Biomaterials (2022-2023)
  • Centenary Prize, Imperial College, London (2009)
  • Dorothy Hodgkins Scholarship
  • Best Podium Presentation Award, International Society for Ceramics in Medicine
  • IDEA League Grant (for her research work at ETH Zurich)
Research Projects: 

05/2022- 08/2023 

Effect of zinc, silver and cerium oxide doped borate bioactive glass- based nanofibers on neural differentiation

Host: Prof. Aldo Boccaccini

Friedrich-Alexander-Universität Erlangen-Nürnberg

Humboldt Fellow as an Experienced Researcher, 3000 EUR per month

Role: Researcher

05/2021-05/2023

The comparison of 3D printed Poly(lactide-co-glycolide) acid  (PLGA) and Carboxymethly Cellulose-Gelatin-based Composites

Boğaziçi University Research Project Fund Role: Principle Investigator

03/2020-03/2023

Examination of Osteogenic Gene Expression of Carbon Nanostructure Reinforced Injectable Bone Scaffolds

Boğaziçi University Research Project

Role: Principle Investigator

10/2017-10/2020

Mechanical Properties of Injectable Bone Scaffolds Reinforced with Carbon  Nanostructures and Investigation of Its Effect on Osteogenic  Differentiation 

Scientific Research Council of Turkey (TUBITAK)

12/2017 - 10/2019

Graphene Oxide as a Drug Carrier for Delivery of Zoledronate in Metabolic Bone Disease and Secondary Bone Cancer Treatment,   

Boğaziçi University Research Project (Fund: 35.983,34 TL(£7435))

Role: Principle Investigator

11/2016 - 07/2019

Synthesis and Characterization of Bisphosphonate Loaded Injectable Bone Substitutes,

Boğaziçi University Research Project (Fund: 35.998,77 TL)(£8867)

Role: Principle Investigator

03/2016 - 10/2017

Effect of Nano Yttria Containing Zirconium (YSZ) and L-Arginine on Hydroxyapatite (HA) Coatings

Scientific Research Council of Turkey (TUBITAK) Role: Principle Investigator

06/2015- 12/2016

Effect of Graphene Oxide /Biodegradable Nanofiber Composites on  Schwann Cell Behavior,

Boğaziçi University Research Project

Role: Principle Investigator

Publications: 
  1. Arıcı, Ş., Kamali, A. R., & Ege, D. (2024). CMC/Gel/GO 3D-printed cardiac patches: GO and CMC improve flexibility and promote H9C2 cell proliferation, while EDC/NHS enhances stability. Biofabrication, 17(1), 015025.
  2. Lu, H. H., Ege, D., Salehi, S., & Boccaccini, A. R. (2024). Ionic medicine: exploiting metallic ions to stimulate skeletal muscle tissue regeneration. Acta Biomaterialia.
  3. Apaydın, B. B., Çamoğlu, T., Canbek Özdil, Z. C., Gezen‐Ak, D., Ege, D., & Gülsoy, M. (2024). Chitosan‐enhanced sensitivity of mercaptoundecanoic acid (MUA)‐capped gold nanorod based localized surface plasmon resonance (LSPR) biosensor for detection of alpha‐synuclein oligomer biomarker in parkinson’s disease. Biotechnology and Applied Biochemistry.
  4. Wei, S., Liu, Y., Rezaei, A., Ege, D., & Kamali, A. R. (2024). Circular economy approach for thermal regeneration of graphene-encapsulated magnetic nanoparticles as an efficient adsorbent for sustainable wastewater management. Journal of Alloys and Compounds, 1008, 176545.
  5. Faramarzi, M., Shabgard, S., Khalili, V., & Ege, D.* (2024). Exploring the effect of chlorhexidine concentration on the biocorrosion behavior of Ti6Al4V for dental implants. Microscopy Research and Technique, 87(7), 1552-1565.
  6. Khalili, V., Ghaleh, H., Asl, H. N., Ege, D., Dikici, B., Kaseem, M., ... & Eggeler, G. (2024). Assessing the properties of biodegradable magnesium alloy AZ31 protected by a polymer layer on a plasma electrolytic oxidized (PEO) surface. Surface and Coatings Technology, 131002.
  7. Arıcı, Ş., & Ege, D. (2024). Effect of gelatin concentration on the mechanical properties and in vitro degradation behaviour of gelatin/carboxymethyl cellulose-based 3D printed scaffolds. MRS Advances, 1-7.
  8. Ege, D.*, & Arıcı, Ş. (2024). Investigation of effect of processing parameters of 3D printed NHS/EDC crosslinked carboxy methyl cellulose/gelatin hydrogels with machine learning techniques. Materials Research Express, 11(4), 045304.
  9. Ege, D.*, & Boccaccini, A. R. (2024). Investigating the Effect of Processing and Material Parameters of Alginate Dialdehyde-Gelatin (ADA-GEL)-Based Hydrogels on Stiffness by XGB Machine Learning Model. Bioengineering, 11(5), 415.
  10. Liu, Y., Wei, S., Kamali, B. E., Ege, D., & Kamali, A. R. (2024). Ni0. 4Fe2. 6O4/(Fe, Ni)‑carbon core-shell magnetic mesoporous nanostructure for efficient adsorption and photocatalytic degradation of malachite green from wastewater. Journal of Water Process Engineering, 59, 105019.
  11. Ege, D.*, Lu, H. H., & Boccaccini, A. R. (2024). Bioactive glass and silica particles for skeletal and cardiac muscle tissue regeneration. Tissue Engineering Part B: Reviews.
  12. Kaya, H., Arıcı, Ş., Bulut, O., Bilgili, F., & Ege, D*. (2023). CNT incorporation improves the resolution and stability of porous 3D printed PLGA/HA/CNT scaffolds for bone regeneration. Biomedical Materials, 18(5), 055028.
  13. Liu, Y., Sun, T., Ege, D., & Kamali, A. R. (2024). Cobalt Oxide-Decorated on Carbon Derived from Onion Skin Biomass for Li-Ion Storage Application. Metals, 14(2), 191.
  14. Ege, D.*, & Kamali, A. R. (2024). XGB Modeling Reveals Improvement of Compressive Strength of Cement-Based Composites with Addition of HPMC and Chitosan. Materials, 17(2), 374.
  15. Ege, D., Sertturk, S., Acarkan, B., & Ademoglu, A. (2023). Machine learning models to predict the relationship between printing parameters and tensile strength of 3D Poly (lactic acid) scaffolds for tissue engineering applications. Biomedical Physics & Engineering Express, 9(6), 065014.
  16. Kaya, H., Arıcı, Ş., Bulut, O., Bilgili, F., & Ege, D. (2023). CNT incorporation improves the resolution and stability of porous 3D printed PLGA/HA/CNT scaffolds for bone regeneration. Biomedical Materials, 18(5), 055028.
  17. Ege, D., Pourshahrestani, S., Iorio, F., Reinfelder, H., de Ligny, D., & Boccaccini, A. R. (2023). Processing and characterization of aligned electrospun gelatin/polycaprolactone nanofiber mats incorporating borate glass (13-93B3) microparticles. Biomedical Materials, 18(5), 055030.
  18. Duru, İ., Büyük, N. İ., Torun Köse, G., Marques, D. W., Bruce, K. A., Martin, J. R., & Ege, D. (2023). Incorporating the antioxidant fullerenol into calcium phosphate bone cements increases cellular osteogenesis without compromising physical cement characteristics. Advanced Engineering Materials, 25(17), 2300301.
  19. Ege, D.*, Hasırcı V. (2023) “Is 3D printing promising for osteochondral tissue regeneration?” ACS Applied Bio Materials, 6(4), 1431-1444
  20. Arıcı, Ş., Kaçmaz, E. G., Kamali, A. R., & Ege, D.* (2023). “Influence of graphene oxide and carbon nanotubes on physicochemical properties of bone cements.” Materials Chemistry and Physics, 293, 126961.
  21. Ege, D.*, Nawaz, Q., Beltrán, A. M., & Boccaccini, A. R. (2022). “Effect of Boron-Doped Mesoporous Bioactive Glass Nanoparticles on C2C12 Cell Viability and Differentiation: Potential for Muscle Tissue Application.” ACS Biomaterials Science & Engineering, 8(12), 5273-5283.
  22. Ege, D.*, Zheng, K., & Boccaccini, A. R. (2022). “Borate Bioactive Glasses (BBG): Bone Regeneration, Wound Healing Applications, and Future Directions.” ACS Applied Bio Materials, 5(8), 3608-3622.
  23.  Ege, D*. 2021 "Action Mechanisms of Curcumin in Alzheimer’s Disease and Its Brain Targeted  Delivery." Materials, 14: 3332–3353.
  24. Oğuz, Ö. D., Ege, D*. 2021 "Effect of Zoledronic Acid and Graphene Oxide on the Physical and In Vitro Properties of Injectable Bone Substitutes." Materials Science and Engineering: C,  120:111758 -111771.
  25. Güben E., Arıcı Ş., Bayır D., Bozdağ E., Ege D*. (2020) “Preparation of Calcium Phosphate / Carboxymethyl Cellulose-based Bone Cements” Bioinspired, Biomimetic and Nanobiomaterials 9(3),155-163 
  26. Boran G., Tavakoli S., Dierking I., Kamali AR., Ege D*. (2020) “Synergistic effect of graphene oxide and zoledronic acid for osteoporosis and cancer treatment” Scientific Reports, 10(1), 1-12
  27. Demir Oğuz Ö., Ege D.* (2019). “Preparation of Graphene Oxide-reinforced Calcium Phosphate /Calcium Sulfate/Methylcellulose-based Injectable Bone Substitutes” MRS Communications, 9(4), 1174-1180.
  28. Güben E., Ege D.* (2019). “Physico-chemical Effects of Gelatin Addition in Carboxymethylcellulose and Calcium Phosphate Cement-based Nanocomposites” MRS Advances, 1-7.
  29. Duru İ., Ege D.* (2018). “Self-Assembly of L-Arginine on Electrophoretically Deposited Hydroxyapatite Coatings” ChemistrySelect, 3(31), 9041-9045.
  30. Demir Oğuz Ö., Ege D.* (2018). “Rheological and Mechanical Properties of Thermoresponsive Methylcellulose/Calcium Phosphate-based Injectable Bone Substitutes” Materials, 11(4), 604-621.
  31. Kaya H., Bulut O., Kamali AR., Ege D.* (2018). “L-Arginine Modified Multiwalled Carbon Nanotube/Sulfonated Poly(etheretherketone) Nanocomposite Films for Biomedical Applications” Applied Surface Science, 444, 168-176.
  32. Tavakoli S.*, Ege D. (2018). “Graphene Oxide as a Drug Carrier for Delivery of Zoledronic Acid in Secondary Bone Cancer Treatment” MRS Advances, 4(21), 1231-1236.
  33. Ege D.*, Kamali AR., Boccaccini AR. (2017). “Graphene Oxide/Polymer-based Biomaterials” Advanced Engineering Materials, 19(12), 16-34.
  34. Ege D.*, Duru İ., Kamali AR., Boccaccini AR. (2017). “Nitride, Zirconia, Alumina, and Carbide Coatings on Ti6Al4V Femoral Heads: Effect of Deposition Techniques on Mechanical and Tribological Properties” Advanced Engineering Materials, 19(11), 49-54.
  35. Duru İ., Ege D.*, Kamali AR. (2016). “Graphene Oxides for Removal of Heavy and Precious Metals from Wastewater” Journal of Materials Science, 51(13), 6097-6116.
  36. Öztatli H, Ege D.* (2016). “Physical and Chemical Properties of Poly(l-lactic  acid) Graphene Oxide Nanofibers for Nerve Regenerations” MRS Advances, 2(24), 1291-1296.
  37. Ege D.*, Best S., Cameron R. (2014). “The Degradation Behaviour of Nanoscale HA/PLGA and TCP/PLGA Composites” Bioinspired, Biomimetic and Nanobiomaterials, 3(2), 85-93.
  38. Ege D.,* Lee K., Bismarck A., Serena B., Cameron R. (2011). “Evaluation of the Degradation Properties of Carbonate Substituted Hydroxyapatite Poly(caprolactone) Composites” Key Engineering Materials, 493494, 120-125.
  39. Mohn D.*, Ege D.+, Feldman K., Schneider Ol., Imfeld T., Boccaccini AR., Stark W. (2010). “Spherical Calcium Phosphate Nanoparticle Fillers Allow Polymer Processing of Bone Fixation Devices with High Bioactivity” Polymer Engineering Science, 50(5), 952-960.  

(+: Contributed equally to this study)

Phone Number: 

+90 216 516 34 38

E-Mail: 
duygu.ege@bogazici.edu.tr
Courses: 

BM 541 Biological Materials

BM 597 Characterisation of Biomedical Samples

BM 682 Phase transformation and Heat Treatment of Biomaterials